Harnessing Nature's Most Powerful
Weapon Against Disease
The Human Immune System
Harnessing Nature's Most Powerful
Weapon Against Disease
The Human Immune System
How We’re Different: We use the human immune system, nature's most powerful weapon against disease, via its “memory” immune response.
Through genetic recombination at cell genesis, each human immune system produces millions of unique memory B-cells, and thus antibodies to fight disease.
Gene recombination during B-cell maturation results in 1 out of 15,000,000 possible antibody variants per B-cell
Each unique antibody has the potential to bind to a target antigen (bacterial, viral, or cancer proteins).
The Immune System's Unique Memory
Memory B-Cells
Retain Immunity
Memory B-cells are a sub-type of B-cells that have been in contact with the antigen previously. Memory B-cells, which persist in your bloodstream, retain memory of the antigen via specific antibodies that are anchored on the cell surface. Anchored antibodies are receptors allowing Memory B-cells to respond quickly to a second exposure.
When they do encounter an antigen again, memory B-cells proliferate and differentiate into plasma B-cells. These plasma B-cells release antibodies that can fight disease by binding to the antigen cell and rendering them inactive.
Antigen Deactivation
Healthy Blood Donor
Trellis: Turning Natural Immunities into Therapeutics
Each person produces millions of unique memory B-cells, and thus unique antibodies, throughout life.
This antibody reservoir provides an abundant source for discovering powerful therapeutics.
1) We collect the entire memory B-cell repertoire from healthy donor blood.
We identify specific antibodies against bacterial and viral antigens as well as cancer Immune Checkpoint Modulators (ICMs) and Tumor-associated Antigens (TAAs).
2) We use our CellSpot platform to clone the most effective antibodies.
Certain individuals have more effective antibodies than others. We can identify the best ones across several parameters.
Nonimmune Patient
3) The favorable features of the most effective antibodies are engineered into a therapeutic product that can be manufactured at commercial scale.
Because these are native human antibodies, they may be safely transferred to other humans without expecting toxicity.
